Very likely yes. Aside from losing all warranty and possibly destroying any value the car has, turbocharging also hurts the overall sound of the natural aspirated V12 and likely performance in different ways. The added extra power add turbo lag. There is always lag with turbocharging. The power delivery is not uniform. Added weight to the rear.
Check out DLM’s Turbocharged Lamborghini Aventador. How do you like it?
The grunt and roar from the bull is absent.
Here is an Armytrix exhaust on a Lamborghini Aventador. All natural.